Peptides and Peptide Fragments

AOD9604 - also known as hGH Fragment 177-191 and C-Terminus hGH (Tyr-hGH_177-199)
AOD9604 is a synthetic analogue of the lipolytic domain of human growth hormone. AOD9604 is being studied for its promising potential of one day being developed into an orally usable and safe therapeutic agent for the treatment of obesity. The results of recent animal studies suggest that AOD9604 causes an increase in lipolytic activity and that long term treatment with AOD9604, in contrast to hGH, will have no adverse effect on insulin sensitivity.    Click here to buy AOD9604

CJC-1295 - also known as CJC1295 DAC and MPA-Lys³⁰, D-Ala², Gln⁸, Ala¹⁵, Leu²⁷-GRF amide
CJC-1295, a tetrasubstituted analog of GRF 1-29, has a D-Ala at the 2-position, a Gln at the 8-position to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, an Ala at position 15 to enhance bioactivity, and a Leu at position 27 to prevent methionine oxidation along with the MPA-Lys at the C terminus. CJC-1295 is a maleimido derivative of GRF 1-29, which is modified in such a way that it has the ability to bioconjugate with serum albumin, thus increasing its half-life and possible therapeutic window.    Click here to buy CJC-1295 DAC

GHRH - also known as Growth Hormone Releasing Hormone and GRF (1-44)
Growth-hormone-releasing hormone GHRH is a peptide hormone consisting of 44 amino acids which is produced in the arcuate nucleus of the hypothalamus. Somatostatin and GHRH are secreted in alternation, giving rise to the markedly pulsatile secretion of GH. GHRH stimulates GH production and release by binding to the GHRH Receptor in the anterior pituitary. GRF (1-29) is considered to be the shortest, fully functional fragment of GHRH (GRF 1-44).    Click here to buy GHRH

GHRP-2 - also known as Growth Hormone Releasing Peptide-2 and GHRH-2
GHRP-2 is a single, non-glycosylated polypeptide chain containing 6 amino acids that has been shown to act directly on pituitary somatotrophs to stimulate GH release. GHRP-2 is considered to be one of the most potent members of the GH-Releasing Peptide family. Numerous studies have shown GHRP-2 to be effective via the oral, intranasal, sc, as well as the iv route of administration, however this peptide has not yet been approved for human usage.    Click here to buy GHRP-2

GHRP-6 - also known as Growth Hormone Releasing Peptide-6, GH-Releasing Hexapeptide and GHRH-6
Growth hormone (GH) release is stimulated by a variety of synthetic secretagogues, of which growth hormone-releasing hexapeptide (GHRP-6) has been most thoroughly studied. GHRP-6 is thought to have actions at both pituitary and hypothalamic sites. A recent study in normal mice that were administered GHRP-6 showed significant differences in body composition, muscle growth, glucose metabolism, memory and cardiac function.    Click here to buy GHRP-6

Hexarelin - also known as HEX, Hexarelin Acetate and Examorelin
Hexarelin, a powerful GHRP, is more resistant to proteolytic degradation than GHRP-6. Recent studies have demostrated that Hexarelin is capable of causing profound GH release in normal subjects after oral, intranasal, iv, and sc administration and that chronic Hexarelin therapy results in a partial and reversible attenuation of the Growth Hormone response.The therapeutic potential of long term Hexarelin usage requires further research and investigation.    Click here to buy Hexarelin

hGH Frag 176-191 - also known as Human Growth Hormone Fragment (176-191)
Fragment 176-191 is a stabilized region of Growth Hormone, which is less than 10% of the total size of the GH molecule. Scientists at Monash University discovered that the fat loss effect of GH is controlled by the small region near the C-terminus, namely amino acids 176-191. GH Frag 176-191 does not influence growth and insulin resistance as reported by numerous studies, but rather it stimulates lipolysis and significantly slows down lipogenesis.    Click here to buy Fragment 176-191

Ipamorelin - also known as NNC 26-0161
Ipamorelin is a pentapeptide, which displays high GH releasing potency and efficacy. Ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of (GHRP)-1. In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6. A pharmacological profiling clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor. Ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation.    Click here to buy Ipamorelin

Modified GRF 1-29 - also known as D-Ala², Gln⁸, Ala¹⁵, Leu²⁷-GRF amide
Modified GRF (1-29) a tetrasubstituted analog of GRF 1-29 that has a D-Ala at the 2-position, a Gln at the 8-position to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, an Ala at position 15 to enhance bioactivity, and a Leu at position 27 to prevent methionine oxidation. Mod GRF 1-29 is modified in such a way that increasing its half-life and possible therapeutic window, but in a more natural pulsatile manner similar to GRF 1-44.    Click here to buy Modified GRF 1-29

Sermorelin - also known as GRF 1-29 and GRF 1-29 Amide
Sermorelin is a growth hormone releasing hormone analogue which is a 29-amino acid polypeptide representing the 1-29 fragment from endogenous human growth hormone releasing hormone, and is thought to be the shortest fully functional fragment of GHRH.    Click here to buy Sermorelin

α-Melanocyte-Stimulating Hormone Analogues (Melanotan Peptides)

Melanotan-1 - also known as Afamelanotide
Melanotan-1 is a synthetic analog of the naturally occurring melanocortin peptide hormone alpha-melanocyte stimulating hormone (α-MSH). It has been shown to induce skin pigmentation through melanogenesis. Melanotan-1 is a non selective agonist of the melanocortin receptors (MC1R,MC3-5R) and as an analogue of α-MSH, its mechanism of action is biomimicry of the natural mammalian tanning process.    Click here to buy Melanotan-1

Melanotan II - also known as Melanotan-II and Melanotan 2
Melanotan II is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis, a process responsible for pigmentation of the skin. This peptide hormone, called alpha-Melanocyte stimulating hormone or MSH, activates certain melanocortin receptors in the process of exerting its effects. Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido via these melanocortin receptors. As a result, Melanotan II has been shown in studies to exhibit appetite suppressant, lipolytic, and libido-enhancing effects in addition to promoting skin tanning. Melanotan II has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to Melanotan II's melanogenesis-stimulating properties. Additionally, Melanotan II has been studied at length as a potential remedy for the treatment of sexual dysfunction.    Click here to buy Melanotan II

PT-141 - also known as Bremelanotide
PT-141 Bremelanotide was developed from the peptide hormone Melanotan II which underwent testing as a possible sunless tanning agent. In initial testing, Melanotan II did induce tanning but additionally caused sexual arousal and spontaneous erections as unexpected side effects. In studies, PT-141 was shown in an animal model to be effective in treating sexual dysfunction in both men (erectile dysfunction) and women (sexual arousal disorder).    Click here to buy PT-141

Insulin-Like Growth Factor (IGF-1) Proteins and Peptides

IGF-1 DES, Insulin-Like Growth Factor-1 Des (1-3) Human Recombinant (Receptor Grade)
IGF-I Des(1-3), also referred to as IGF-1 (4-70), is a single, non-glycosylated, polypeptide chain containing 67 amino acids (aa 4-70 of IGF-1) and having a molecular mass of 7372 Dalton.    Click here to buy IGF-1 DES

IGF-1 LR3, Insulin-like Growth Factor-1 Long Arg3 Human Recombinant (Receptor Grade)
Human Long Arg3 Insulin-like Growth Factor-I is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. IGF-1 LR3 was engineered by scientists with the purpose of increasing biological activity. Human IGf-1 LR3 is significantly more potent than human IGF-I in vitro. The enhanced potency is due to the markedly decreased binding of human IGF-1 LR3 to IGF binding proteins which normally inhibit the biological actions of IGFs.    Click here to buy IGF-1 LR3

IGF-2, Insulin-Like Growth Factor-2 Human Recombinant
IGF-2 is a member of the insulin family of polypeptide growth factors that is involved in development and growth. Insulin-Like Growth Factor-2 contains 67 amino acids and has a molecular mass of 7505 Dalton.    Click here to buy IGF-2

MGF, Human Mechano Growth Factor, IGF-1 Ec
By alternative splicing the IGF-1 gene produces several different transcripts, including IGF-1Ec (MGF). MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. MGF is apparently involved in the activation of muscle satellite (stem) cells, which donate nuclei to the muscle fibers for repair.    Click here to buy MGF (IGF-1Ec)

PEG MGF, PEGylated Human Mechano Growth Factor, IGF-1 Ec PEG
PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and in theory this will allow the MGF to be carried through the blood stream without being broken down.    Click here to buy PEG IGF-1Ec Mechano Growth Factor

Cosmetic Peptides

Acetyl Hexapeptide-3 - also known as Argireline
Acetyl hexapeptide-3 is a peptide fragment of SNAP-25, a substrate of Botox (Botulinum toxin). Acetyl hexapeptide-3 has been shown in research studies to reduce the deep wrinkles and lines that occur around the forehead and eyes when applied as a solution to specific areas of the face. Acetyl hexapeptide-3 inhibits the reactions that cause muscles to move or contract – for example when forming facial expressions such as smiling or frowning.    Click here to buy Acetyl Hexapeptide-3

Copper peptide GHK-Cu - aslo known as GHK or GHK-Cu
GHK-Cu is a tripeptide that has a very strong affinity for copper (II). Scientific studies conducted in different research laboratories have suggested that GHK-Cu can promote activation of wound healing, attraction of immune cells, antioxidant and anti-inflammatory effects, stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts and promotion of blood vessels growth.    Click here to buy GHK-Cu

Palmitoyl-Pentapeptide 3 - also known as Matrixyl
Known by the trade name Matrixyl, Palmitoyl-Pentapeptide 3 is a fatty acid mixed with amino acids. The only research showing any significance for skin rejuvenation was carried out by the ingredient manufacturer, Sederma. Without independent substantiation there is no way to know how accurate this research is.    Click here to buy Palmitoyl-Pentapeptide 3

Acetyl Glutamyl Heptapeptide-1 also known as SNAP-8
Acetyl Glutamyl Heptapeptide-1(SNAP-8) is a unique new peptide that has been shown in recent studies to both reduce the degree of existing facial wrinkles and has been demonstrated to be effective against the development of wrinkles. The anti wrinkle octapeptide SNAP-8 is an elongation of the famous hexapeptide Acetyl Hexapeptide-3, which is more commonly known as Argireline.    Click here to buy SNAP-8

Miscellaneous Peptides, Proteins and Amino Acid Derivatives

ACTH (1-39) Adrenocorticotropic Hormone, Human
ACTH (1-39) is a component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Studies have demonstrated it possibly induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes.    Click here to buy ACTH (1-39)

Oxytocin
Oxytocin (Oxt) is a mammalian neurohypophysial hormone that acts primarily as a neuromodulator in the brain. Oxytocin plays key roles in sexual reproduction and is released in large amounts after distension of the cervix and uterus during labor, facilitating birth, maternal bonding, and, after stimulation of the nipples through breastfeeding. Recent studies have begun to investigate oxytocin's role in various behaviors, including orgasm, social recognition, pair bonding, anxiety, and maternal behaviors    Click here to buy Oxytocin

TB-500, Thymosin beta-4
Thymosin beta-4 TB-500 is a protein that in humans is encoded by the TMSB4X gene and consists (in humans) of 43 amino acids. TB-500 is also involved in cell proliferation, migration, and differentiation.    Click here to buy TB-500

Thyrotropin-releasing hormone (TRH) - also known as thyroliberin or protirelin
TRH is a tropic, tripeptidal hormone that stimulates the release of TSH (thyroid-stimulating hormone) and prolactin from the anterior pituitary.    Click here to buy Thyrotropin-releasing hormone (TRH)